The Small Business Innovation Research (SBIR) and Small Business Technology Transfer (STTR) programs encourage domestic small businesses to engage in Federal Research/Research and Development (R/R&D) that has the potential for commercialization.
Validated assays, specimen handling procedures, and reagent sources for clinical pharmacodynamic studies and Training Certification
Patient-derived models including patient-derived xenografts and in vivo patient-derived cell cultures annotated with clinical observations and molecular characterizations
Provides a focused consultation with NCI staff regarding the critical path considerations for developing novel investigational drugs intended for human use (i.e. small molecule or biologic, therapeutic or imaging drugs) and how to effectively communicate with the FDA.
Helps researchers identify potentially promising combinations of cancer drugs by providing data and analysis tools showing how well pairs of FDA-approved cancer drugs performed in killing tumor cells from the NCI-60 Human Tumor Cell Lines.
This software provides an easy to use, fast compiled C program that runs in a DOS window for computing optimal and minimax two-stage designs for phase II clinical trials.
Through its Clinical and Translational Science Awards (CTSA) Program, NCATS is developing a single institutional review board (IRB) platform for multisite clinical studies: the NCATS Streamlined, Multisite, Accelerated Resources for Trials (SMART) IRB Platform. The goal is to provide flexible …
Knowing therapy development is a challenging process, NINDS asked its biologic consultant contractors to generate guidance documents to better prepare investigators.
Screening services, molecular targeting, drug development services
The NCI Formulary is particularly useful to investigators who would like to perform combination studies that focus on agents targeting molecular pathways from multiple collaborating pharmaceutical companies. A goal of the NCI Formulary is to improve the clinical trial implementation …
ResearchMatch is a free, secure registry, making it easier for the public to volunteer and to become involved in clinical research studies that contribute to improved human health. The tool is expected to reduce recruitment costs, increase enrollment and speed …
REDCap is an easy-to-use, freely available tool for clinical study management and data capture, providing investigators with the ability to build and manage online surveys and databases.
Offers well-established, broadly validated measures of phenotypic traits and environmental exposures of interest to investigators in human genomics, epidemiology and biomedical research.
Public website developed by NIH’s National Institute of Allergy and Infectious Diseases to help researchers navigate country-specific regulatory information as they plan and implement clinical trials.
Online glossary developed by a Food and Drug Administration and NIH joint committee to clarify terms used in translational science and medical product development, with a focus on study endpoints and biomarkers.
Training workshops designed to share best practices and advice on robust assay design, development and implementation for researchers involved in the drug discovery process.
The Assay Guidance Manual initiative delivers resources on best practices within the early stages of development as well as training focusing on robust, early-stage drug discovery assays.
The BrIDGs program assists researchers in advancing promising therapeutic agents through late-stage pre-clinical development toward an Investigational New Drug (IND) application and clinical testing.
TRND program supports pre-clinical development of therapeutic candidates intended to treat rare or neglected disorders, with the goal of enabling an Investigational New Drug (IND) application.